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Description
51, 52, 53 In the small intestine, GPBAR1/TGR5 activation could favorably modulate insulin sensitivity and glucose metabolism through stimulating the secretion of the incretin hormone glucagon-like peptide-1 (GLP-1) by ileal enteroendocrine L cells
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In terms of glycemic control, these agents affect glucose metabolism through distinct pathways: GLP-1RAs enhance glycemic control by stimulating glucose-dependent insulin secretion, while SGLT2is lower blood glucose levels by inhibiting glucose reabsorption in the proximal renal tubules, leading to increased urinary glucose excretion
These properties meant exenatide could potentially be injected at intervals (e.g
