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Among these potential key players, Roche continues to stand out with multiple obesity candidates within its pipeline, all in phase II trials (as of November 2025), and it is expected to enter the market in 2029 or later

The exact mechanism how DPP4 inhibitors augment insulin secretion and increase -cell mass in vitro and in vivo is still not fully understood, since not all these effects could be explained by elevated GLP-1 level or improved glycemic control associated with less glucotoxicity

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