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Weight Reduction Mechanisms and Outcomes The weight-reducing effects of GLP-1 RAs are primarily attributed to reduced food intake rather than increased energy expenditure

Shared decision-making between patient and provider is essential for optimizing outcomes

American Psychiatric Association (APA) Clinical reviews show ketamine surpasses many antidepressants and anti-anxiety drugs, especially for treatment-resistant cases without emotional numbing or dependency risks

Therefore, future prospective studies with detailed medication profiles are warranted to inform causality, minimize study bias, and provide a comparative evaluation of GLP-1 RAs safety and clinical outcomes