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The effects were inhibited by coinfusion with exendin(939), a specific antagonist of the GLP-1R, indicating that active GLP-1 exerts its vascular protective effects through the classical GLP-1R, which is expressed in vascular smooth muscle cells and endothelial cells

Key takeaways Saxenda is available in a generic form called liraglutide for weight management

This is partly due to modulation of inflammatory signaling pathways and improvement of mucosal function, for example, by modulating the metabolism of bile acids [18, 19], and by increasing beneficial microbes that support gut homeostasis [4]