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Description
Gastrointestinal symptoms, such as nausea and bloating, are usually temporary and tend to resolve as treatment continues, especially once a stable dose is reached
Bethel MA, Diaz R, Castellana N, et al
Glucagon-Like Peptide-1 Modulates Cholesterol Homeostasis by Suppressing the miR-19b-Induced Downregulation of ABCA1
A study published in Diabetes, Obesity and Metabolism (Frias et al., 2021) from an early phase 2 comparison found that tirzepatide produced dose-dependent weight loss that exceeded semaglutide 1 mg across all dose levels tested, confirming the advantage of the dual mechanism
