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[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Mietlicki-Baase E.G., Ortinski P.I., Reiner D.J., Sinon C.G., McCutcheon J.E., Pierce R.C., Roitman M.F., Hayes M.R
, Gillum, M
Clinical Effects of GLP-1 RAs in T2D The glycaemic effects, weight reduction and potential CV effects of evolving GLP-1 RAs in the treatment of T2D have been reviewed extensively in the last decade [7, 11, 43]
In the liver, insulin activates STAT3 transcription factors in hepatocytes that suppress the gene expression of gluconeogenic enzymes, thereby decreasing hepatic glucose production
