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Description
At steady state, body burden is approximately 1015 times the single-dose absorbed amount, bringing plasma concentrations into the therapeutic range despite extremely low and variable per-dose absorption
For type 2 diabetes, NICE recommends continuing GLP-1 therapy only if HbA1c falls by 11 mmol/mol AND body weight reduces by 3% at 6 months

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Understanding your genetic predispositions can support a more informed conversation with your provider about sleep management during GLP-1 therapy
