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& Cheetham, J

For patients with obesity-related complications, ongoing treatment helps manage these conditions alongside weight management

Accumulating evidence demonstrates that GLP-1RAs exert heterogeneous effects across different tumor types (Table 1)

Understanding this dual role has important therapeutic implications, as G protein-biased GLP-1 receptor agonists with reduced -arrestin recruitment show enhanced anti-hyperglycemic efficacy through avoidance of receptor desensitization, while the requirement for -arrestin-2 in ERK/CREB activation at therapeutic concentrations explains why complete elimination of -arrestin-2 recruitment may not be optimal for all applications