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The balance of benefits and risks outside the licensed indication has not been shown to be favourable

Let's dive into how this innovative treatment is changing the way we approach metabolic health

Although studies have found that metformin also affects 18 F-FDG accumulation in the colon, the mechanism is unclear ( 2.2 Increased GLP-1 secretion Metformin enhances the release of glucagon-like peptide-1 (GLP-1) from the intestines, potentially contributing to its ability to lower blood sugar levels ( The mechanism by which metformin increases GLP-1 secretion in the gastrointestinal tract is currently unclear

The medication's effect on gastric emptying and bowel motility creates a physiological environment where pre-existing gastrointestinal conditions might become symptomatic
