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On tirzepatide, it most commonly manifests as a dull, diffuse soreness in the legs, arms, or trunk

We do not know what the future will look like, but for now, it is possible that people will be discontinued on their medication, whether semaglutide or tirzepatide, while the manufacturers ramp up supply to try to meet this unprecedented demand

The primary cause is the musculoskeletal adjustment to changing body weight, though inflammation from dehydration and nutrient deficiencies can amplify the sensation

A person experiencing these side effects might not be in the best condition to undergo a plasma donation, which requires good hydration and stable blood pressure