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Researchers discovered that after 68-weeks, those who received semaglutide experienced an average weight loss of 14.9%, while those who received a placebo injection experienced a weight change of only 2.4%

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For diabetes management, if HbA1c remains above target despite maximal tirzepatide dosing, combination therapy with metformin, SGLT2 inhibitors, or basal insulin should be considered based on individual patient factors and contraindications
