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An additional consideration for patients without known prior atrial fibrillation is that they have likely never been on any rate-controlling agents and may have variable initial responses to these interventions

Yes, they can be used together in some cases because they serve different purposes

Mine is a different [medication] than people assume, but I ended up having to do that too, because my bloodwork got so bad, said Clarkson who, at just under 5-foot 4 inches, noted she weighed about 203 pounds at her heaviest

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