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Leptin transport across the BBB is impaired in obesity (Burguera et al., Hyperleptinemia, which either manifests gradually in association with age-related obesity or is produced rapidly by the consumption of energy-enriched diets, is associated with decreased brain leptin concentrations in rodents and humans (Banks et al., 2008

They offer a more targeted approach than traditional weight-loss medications, which often come with a long list of side effects

Food and Drug Administration (FDA) has granted accelerated approval for Rezdiffra (resmetirom) in conjunction with diet and exercise for the treatment of adults with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis), which is the first and only medication approved by the FDA for the treatment of NASH

What was studied: Mean change in body weight How long participants took semaglutide: 68 weeks Outcome : The semaglutide group had a mean change in body weight of -15.3 kilograms (33.73 pounds), compared to -2.6 kilograms (5.73 pounds) in the placebo group over the 68 weeks