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(3) GDF8 and ActA blocking antibodies on their own (-MSTN/-ActA)

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Bone health is influenced by the interaction between osteoblasts (bone forming cells, OBs) and osteoclasts (bone resorbing cells, OCs), which are primarily regulated by the Wnt/-catenin pathway and the receptor activator of nuclear factor-B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) axis, respectively (74)

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