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GLP-1RAs have been proven to reduce the risk of major adverse cardiovascular events (MACE) occurrence, including death from cardiovascular causes, non-fatal myocardial infarction and non-fatal stroke, as well as all-cause mortality in T2DM and patients with obesity ( The glucocorticoid receptors are present in GLP-1-producing cells, and their activation diminishes the secretory responsiveness of these cells ( 4.1 Efficacy of GLP-1 receptor agonist therapy in SID Considering their beneficial effects on body weight, effective glycemic control, and low risk of hypoglycaemia, GLP-1 RAs may be suitable therapeutic options for SID and SIH, either as adjunctive therapy or as primary treatment

Bone health is influenced by the interaction between osteoblasts (bone forming cells, OBs) and osteoclasts (bone resorbing cells, OCs), which are primarily regulated by the Wnt/-catenin pathway and the receptor activator of nuclear factor-B (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) axis, respectively (74)
