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They had first-mover advantage, and compound exposure

Mice were double- or single-housed and unless otherwise indicated fed ad libitum with either a regular chow (1314, Altromin or 5L0D, LabDiet) or HFD (58% fat, D12331, Research Diets) under constant ambient conditions of 22 2 C with constant humidity (4565%) and a 12 h:12 h light:dark cycle

The injectable format of most GLP-1 RAs, and the development of oral forms (like Rybelsus, an oral semaglutide) that require specific absorption enhancers, underscore the challenge of getting these large molecules into the body efficiently

Microdosing is usually done through structured programs, such as personalized GLP-1 injections or dedicated microdose GLP-1 options, rather than self-experimentation