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Both semaglutide and opioids slow gastric motility, meaning their combination can lead to severe constipation, bowel obstruction, or other serious GI complications
Other medications that can facilitate weight loss in T2D, notably the SGLT2 inhibitors, may prove more acceptable and better tolerated than GLP-1 RAs
Finally, coincidental conditions must always be considered
Int J Endocrinol 2012
