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At 24 weeks, the mean relative change from baseline in liver fat was a 42.9% reduction in the 1 mg group, a 57.0% reduction at 4 mg, an 81.4% reduction at 8 mg, and an 82.4% reduction at the 12 mg dose

Where estrogen works to restore the hormonal environment that governs fat distribution and metabolic regulation, GLP-1 therapy directly reduces caloric intake by recalibrating appetite signaling, improves glycemic control through multiple mechanisms, and drives the reduction of visceral fat mass that estrogen alone cannot reliably produce in the setting of significant metabolic burden

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Retatrutide should only be used under the supervision of a qualified healthcare provider with proper monitoring.
