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In summary, our approach demonstrates the feasibility of using peptide-mediated targeting to achieve cell-specific ionotropic receptor modulation and highlights the therapeutic potential of unimolecular mixed GLP-1 receptor agonism and NMDA receptor antagonism for safe and effective obesity treatment.
Despite substantial mechanistic and preclinical evidence indicating neuroprotective effects, translating these findings into clinical benefits has proven challenging
The preliminary data suggest positive benefits
