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E., Poller, B., Castelli, M

In addition to POMC, other markers in the ARC that potentially represent targets for GLP-1RAs are currently being studied

If anything, many patients report the opposite effect: once weight decreases and metabolic health improves, people often experience increased energy, improved mood, and greater confidence

The STEP 1 trial for semaglutide 2.4mg demonstrated a mean body weight reduction of approximately 14.9% over 68 weeks in adults with obesity. The SURMOUNT-1 trial for tirzepatide showed reductions of up to 22.5% at the highest dose. These are outcomes that approach the efficacy of bariatric surgery in some patient cohorts