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"It's a malfunction, basically, of our body's ability to compute energy balance." Individuals with obesity receive body signals telling them that they are hungrier, prompting them to find and consume more food to increase energy balance, Alexander added

As patients experience significant appetite suppression and reduced food intake, they may experience transient symptoms including fatigue, headache, and body discomfort

This is not true pharmacological tolerance in the classic sense, but rather the body finding a new equilibrium at the current level of receptor stimulation

In a similar study, patients with an A1C 7.5% reduced their insulin glargine dose by 30% when beginning tirzepatide