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Moreover, administering ghrelin intravenously in participants with alcohol-dependence increased the anticipatory alcohol signal in the amygdala during alcohol clamp, and modulated an anticipatory food signal in the medial orbitofrontal cortex and NAc differentially, depending on alcohol consumption (Farokhnia et al., 2018)

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Based on the findings of such CVOTs, management guidelines have been updated to recommend the use of GLP-1RAs and SGLT-2is with proven CV benefits as first-line therapies in people with type 2 diabetes at high or very high risk of, or with atherosclerotic CV disease [8, 9]

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