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Activating both at full dose simultaneously, with no titration runway, is what community sources describe as the failure mode that drives discontinuation

CMS unveils $50 GLP-1 prescriptions for Medicare patients The Centers for Medicare & Medicaid Services announced Wednesday that it has developed a framework for Medicare beneficiaries to seek the benefits of GLP-1 diabetes and weight loss medications and have the costs coveredalbeit for an additional monthly premium above and beyond the standard cost of insurance

This dysfunction is further associated with coagulopathy and thrombosis (Wong et al., 2018)

[1] What does this mean for portion sizes