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Thurlow argues that the gut microbiome shifts dramatically over the course of a woman's lifetime peaking around age 40 and that the hormonal changes of perimenopause and menopause accelerate microbial depletion in ways that affect immune function, metabolism, mood, cognition, and bone health

Severe Hypersensitivity and Medication Allergies A documented severe allergy or hypersensitivity reaction to semaglutide, tirzepatide, or other GLP-1 agonists is an absolute contraindication

N Engl J Med 348:383393 Gaede P, Lund-Andersen H, Parving HH, Pedersen O (2008) Effect of a multifactorial intervention on mortality in type 2 diabetes