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The glucagon component is why retatrutide produces greater fat loss, better body composition, more pronounced cardiovascular marker improvements, and more than 80% reduction in liver fat effects that go substantially beyond what appetite suppression alone can explain

When calorie intake drops, as it reliably does on tirzepatide, the body mobilizes stored triglycerides from adipose tissue

Gastrointestinal effectsnausea, vomiting, and constipationare most frequent, typically mild to moderate during dose escalation

If nausea is present early in the day, a smaller option like plain Greek yogurt with granola can work just as well