is glp 1 a peptide Glucagon-Like | C149H226N40O45 | CID 16133831 Frontiers | Glucagon-like peptide-1 receptor

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doi: 10.1152/ajpendo.00419.2016 28 HartterESvobodaTLudvikBSchullerMLellBKuenburgEet al

Mineralocorticoid Receptor Antagonists in the Treatment of Diabetic Kidney Disease: Their Application in the Era of SGLT2 Inhibitors and GLP-1 Receptor Agonists

GLP-1R activation leads to a rapid increase in the levels of cyclic adenosine monophosphate (AMP) and intracellular calcium followed by glucose-dependent insulin release

These agonists not only enhance GLP-1 release but also suppress the expression of pro-inflammatory cytokines, including IL-2, IL-17a, interferon-, and TNF- (Yusta et al., 2015)