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Semaglutide carries a boxed warning for thyroid C-cell tumors in rodent studies and is contraindicated in people with MTC or MEN 2

[7] [8] For weight management, NICE restricts their use to specialist weight management services with specific BMI thresholds and stopping rules

Combined with sensitivity analyses, we infer that the imprecision leading to downgraded evidence quality for certain outcomes may be linked to differences in study follow-up duration: short-term follow-up studies might suffer from increased random error or insufficient statistical power due to inadequate accumulation of cardiovascular events

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