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These findings uncover a non-canonical mechanism of action for GLP-1 analogs, highlighting a specific microbiota-endocannabinoid metabolic pathway as a potential therapeutic target for depression.

Circulation 127, 7485

So getting three faces right was incredibly difficult. Eventually, he made one, and with Tschps experiments in mice, they showed in a 2014 paper that this triple agonist was even more powerful than dual agonists