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It is found that in the clinical follow-up studies of NAFLD patients, compared with the control group, hepatic fat content and ALT levels were not significantly reduced in Lira group and were associated with an increased incidence of gastrointestinal adverse events [118]

The dose starts small and gradually increases over several weeks, primarily to reduce the side effects of nausea, diarrhea, constipation, abdominal pain, and bloating
Many patients notice changes in appetite within weeks, but significant weight loss usually develops gradually over several months
