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Comparative metabolic and hepatic effects of GLP-1-based mono-, dual-, and triple-agonist therapies GLP-1 receptor signaling Intestinal L-cells serve as the primary source of GLP-1 synthesis, which operates via G-protein coupled receptors present in pancreatic beta cells, gastrointestinal and central neural systems, cardiac tissues, and kidneys [26]

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doi: 10.1152/ajpendo.00545.2003

Some research suggests that GLP-1s might cause a thinning of the skin and interrupt signals in the skin that are critical to skin cell turnover, collagen production, and elastin production, he explains