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Epidemiological evidence demonstrates a strong association between obesity and KOA, highlighting shared pathogenic mechanisms

We selected appropriate confounders, such as index year, sex, age, diabetes duration, health screening variables, comorbidities, and antidiabetic drugs, for PS matching to minimize the influence of factors other than GLP-1 RA exposure

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Recently, there has been increased interest in the development of incretins that combine body-weight-lowering and glucose-lowering effects