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These strategies offer several potential advantages over GLP-1 analogs, including a more natural stimulation of GLP-1 pathways, reduced risk of side effects, and the ability to address metabolic dysregulation at its source However, clinical applicability for pharmacological targets to increase sufficient GLP-1 production and promote L-cell differentiation has not been identified

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The FDA did create a new Genetic Metabolic Diseases Advisory Committee in 2024, which expands its capacity to evaluate exactly this kind of therapy

Interestingly, mating with males have been well-documented to impose significant physiological costs on hermaphrodites and to result in drastically shortened lifespan, known as male/mating-induced demise (MID) 57,58