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The firm pointed to the extensive gross-to-net adjustments that the manufacturers are already providing on these drugs. BMO Capital Markets, for its part, wrote in a note to investors, We reiterate that the important comparison remains the difference between the products newly discounted price and the products ultimate net price, including rebates, instead of their list prices

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Liver enzyme elevations (ALT and AST above 3 times the upper limit of normal) occurred at rates similar between orforglipron and placebo groups, with no dose-dependent pattern suggesting drug-related hepatotoxicity

The growing global prevalence of IBD [2] highlights the urgent need to discover new pathways and molecular targets to broaden the therapeutic arsenal available