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In one prospective study, greater than 10% weight loss led to regression in liver fibrosis with greater than 5% weight loss reducing hepatic steatosis
Both LPS- and IL-1induced GLP-1 release partly depends on IL-6 as shown in Il6 / mice (5, 6), although the source of IL-6 that triggers L cells is unclear
GLP-1 receptor agonists are synthetic molecules engineered to mimic the hormone while resisting breakdown, so the signal lasts hours or days instead
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