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However, head-to-head trials and meta-analyses reveal distinct profiles

In T 1 DM, an autoimmune mechanism impairs -cells, leading to insulin deficiency, whereas T 2 DM is characterized by insulin resistance and impaired glucose regulation, where the peripheral action of insulin is compromised (3)

Kaku K., Yamada Y., Watada H., et al., Safety and Efficacy of OnceWeekly Semaglutide vs Additional Oral Antidiabetic Drugs in Japanese People With Inadequately Controlled Type 2 Diabetes: A Randomized Trial, Diabetes, Obesity & Metabolism 20 (2018): 12021212

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Wang A., Tang H., Zhang N., Feng X