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These drugs were initially developed for the treatment and/or management of diabetes, but scientists thought this drug could be a direct cure for obesity as well

A major contributor was prescription drug spending, which rose 9.4% in 2025, driven in part by growing use of GLP-1 medications, some of which have list prices exceeding $1,000 per month, according to various estimates

Pregnancy with T2DM is a high-risk condition for major congenital anomalies, among other adverse outcomes, thus emphasizing the need for glycemic control during this period

Kim T, Nason S, Holleman C et al (2018) Glucagon receptor signaling regulates energy metabolism via hepatic Farnesoid X Receptor and fibroblast growth factor 21