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Step 2Start Fluid Replacement With Monitoring of Electrolytes and Ketones: Fluid resuscitation should be the focus of initial management in EDKA

(2) Preparation of compound 4: activating the compound 3, and carrying out acylation coupling reaction on the activated compound and Arg34GLP-1 (9-37) terminal amino group in the compound 2 under the action of a condensation reagent and alkali to obtain a compound 4

The FDA has approved its use for chronic weight management in adults with a body mass index (BMI) of 30 or more, or a BMI of 27 or more when accompanied by at least one weight-related condition such as high blood pressure, high cholesterol, or type 2 diabetes

2026: o Of outstanding importance o This study provides the first direct clinical evidence that LEAP2 infusion reduces food intake and improves postprandial glucose control in men living with obesity