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However, there are also data suggesting that GLP-1RA use may be associated with worsening mental health disorders, 136 discussed in detail below, and further longitudinal studies are required

For example, GLP-1 enhances L-type Ca 2+ currents through activation of the cAMP-dependent PKA pathway in canine cardiomyocytes [71], whereas when rat hippocampal neurons are pre-incubated with GLP-1 for 24 h, Ca 2+ currents are significantly decreased [58]

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This approach prevents double-dosing, maintains therapeutic consistency, and keeps your medication schedule aligned with your lifestyle