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Additionally, evidence suggests that they may facilitate fat-based weight reduction by influencing adipose tissue metabolism and inflammatory processes

But, "for the group of people we call metabolically healthy obese, if they don't have any [health problems] related to high-BMI, there's nothing that's urgent that you need to lose weight for," says Dunaif

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In the STEP 1 trial published in The New England Journal of Medicine , people taking semaglutide lost more than 15% of their body weight over about 16 months