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The various approaches include the combination of GLP-1R agonists with leptin [912,913], salmon calcitonin [914], PYY [915], CCK [916], insulin [917], adrenomedullin [918], and 3-adrenergic receptor agonists [919], and antagonists at the cannabinoid receptor 1 (CB1) [920], or agonists at the receptors for melanocortin-4 (MC4R) [685] or farnesoid-x (FXR) [921]

So I think thats the big takeaway. Editor's note: This story, originally published Jan