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12 GLP-1RAs also upregulate VTA presynaptic dopamine-2 (D2) receptor transcription, ultimately reducing VTA dopaminergic signaling over time
13 Compared to the shorter SASQ or STAD, three questions may be more cumbersome for all patients, but it is the most reliable, concise screening tool, and should be included in any screening program, in some capacity
Some people respond better to tirzepatide (which also targets GIP) than semaglutide
Furthermore, GLP-1RA use in people with T2D and CKD improves metabolic parameters not achievable with the other DKD therapies
