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Subsequently, the phosphorylated SHP2 together with its adapter molecule growth factor receptor-bound protein 2 (Grb2) activates the downstream ERK signaling cascades, inducing thermogenesis by controlling sympathetic activity on BAT, and promoting the anorectic effects of leptin [136, 137]

Purpose-built for physicians GLP-1 drugs may reduce uterine fibroid risk for women with type 2 diabetes Key takeaways: Compared with metformin and insulin, GLP-1 receptor agonists may protect against new uterine fibroids in women with type 2 diabetes