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These mechanisms may be related to several microbial-derived molecules, such as SCFAs
This can result in a reduced need for thyroid hormone replacement, particularly in patients who initially required higher doses due to obesity-related factors like increased inflammation or altered hormone metabolism
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Conventionally, the selective vulnerability of neuronal populations to disease processes is usually attributed to their inherent properties (i.e., high metabolic rate, ROS generation, and extensive arborisation with increased energy demand) [133,136,137]
