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Below pH 5.5, degradation accelerates significantly due to the peptide isoelectric point at pH 5.4

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NICE guidance recommends regular monitoring of glycaemic control and tolerability for patients on GLP-1 receptor agonists, but not routine cortisol assessment

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Some users report subtle increases in energy levels, reduced appetite, or slight improvements in how clothing fits during this initial phase

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Only a small minority, fewer than 10%, say usage of GLP-1s is viewed positively

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