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These data provide the first prospective evidence to support recent multisociety recommendations advocating for individualized, risk-based management rather than universal discontinuation of GLP-1 RAs

For example, INS , islet amyloid polypeptide ( IAPP ), MAF bZIP transcription factor A ( MAFA ), pancreatic and duodenal homeobox 1 ( PDX1 ), and NK6 homeobox 1 ( NKX6.1 ), exhibited a varying degree of expression in cell subclusters, with the highest expression in -4 cells (Figure 3D)

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However, injectable medications still face certain limitations in terms of convenience, patient adherence, and large-scale supply