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Dosing is protocol-led, adverse events are recorded, and clinicians can stop or adjust treatment if safety concerns arise

The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role

European Medicines Agency (EMA): The European Unions EMA oversees the safety of medicines