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The FDA's recent guidance on obesity drug development has emphasized the importance of patient-reported outcomes and quality of life measures in addition to traditional weight loss endpoints

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Morroniside, an iridoid glycoside derived from the medicinal herb Cornus officinalis , is a potent orthosteric agonist of GLP-1R with significant anti-hypersensitivity effects

Semaglutide reduces major adverse cardiovascular events, heart failure composite, cardiovascular death, and all-cause death in patients with atherosclerotic cardiovascular disease and overweight or obesity and heart failure