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Retatrutide, a single peptide targeting GIP, GLP-1, and glucagon receptors, has shown remarkable results in early-phase studies
10.1038/nrn2867 [DOI] [PubMed] [Google Scholar] Collins S
107 Interestingly, only an estimated 15% of the active GLP-1 reaches the portal vein before the liver, due to the rapid inactivation through DPP-IV
