semaglutide and sertraline FAQ: Can You Take Together with SSRIs? Ozempic and Sertraline Together: Safety

The injectable GLP-1 medications currently on the market have published higher average weight loss figures in their landmark trials: Semaglutide (Wegovy): Demonstrated approximately 14.9% average body weight reduction in the STEP 1 trial

But the authors appropriately noted limitations: the retrospective design, small sample size, and the fact that most patients were already in remission when starting therapy

The amount of endogenous corticosteroids created by the HPA-axis is equivalent to 7.5mg of prednisolone daily (or about 8mg of prednisone daily)

This is because these conditions already involve inflammation and pain in the joints, and the additional strain caused by Ozempic might lead to a worsening of the symptoms