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However, a lack of GLP-1R is also observed to trigger a stress response that boosts fibroblast growth factor 21 and elicits beneficial systemic effects such as memory improvement and glucose homeostasis ( In aging heart tissue, liraglutide is reported to activate IRS1/eNOS/PKG pathways, restoring mitochondrial function by improving mitochondrial membrane potential and reducing oxidative stress ( As we can see, the role of mitochondria regulation and cellular stress response stands at the center of many diseases

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American Journal of Clinical Nutrition