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Description
They work by mimicking the action of naturally occurring GLP-1, an incretin hormone released from the intestine in response to food intake

Causal Inference : What If (CRC Press, 2010)

Although CAR-T cells are effective in hematologic malignancies, their activity in NSCLC is limited by antigen heterogeneity, dysfunction induced by the TME, and inhibitory signaling mediated by PD-1
Lancet 2013;381:117124
